"Roitt's Essential Immunology" has established itself as the book of choice for students of immunology worldwide. This excellent textbook is commonly regarded as 'the best of the immunology primers' and the tenth edition remains at the cutting edge of this fascinating area of science. The trademark of this book is its highly readable introduction to the subject, its emphasis on core knowledge and its excellent four-color artwork. On the tenth edition, Ivan Roitt is joined by Peter Delves, a brilliant teacher from University College London. Together they have extensively updated all aspects of the book to produce a new edition, which will be an invaluable resource to students of immunology and medicine. The tenth edition focuses on: dendritic cells, intraepithelial lymphocytes, NKT and gd T-cells, NK receptors, non-classical MHC presentation of non-peptidic antigens, analysis of TCR-peptide-MHC interactions, gene 'knockouts' and 'knockins', cell signaling pathways, chemokines and their receptors, intimate links between innate and adaptive immunity, regulatory T-cells, Fcg receptors, and activation-induced cell death signaling through pattern recognition systems prions.